What are the best hotels in Otay Mesa?

Holiday Inn Express & Suites San Diego Otay Mesa By IHG is a very popular hotel in Otay Mesa with a score of 7.5 from 599 reviews.

What is a good hotel near Gaslamp Quarter?

With a rating of 8.7/10 from 3,481 reviews, Manchester Grand Hyatt San Diego is a hotel close to Gaslamp Quarter that is well recommended by HotelsCombined users.

What is a good hotel in Otay Mesa near San Diego Convention Center?

For a good hotel near to San Diego Convention Center, consider Manchester Grand Hyatt San Diego - it is rated 8.7/10 from 3,481 HotelsCombined reviews.

Is there a good hotel near La Jolla Cove?

If you’re looking for good hotels near La Jolla Cove, consider La Jolla Shores Hotel (rated 8.2 over 21 reviews).

How much is a cheap hotel in Otay Mesa?

HotelsCombined users have found cheap hotels in Otay Mesa starting from $95 per night in the last 3 days.

What are the most popular landmarks to visit in Otay Mesa?

The top three landmarks in Otay Mesa are: • Gaslamp Quarter, which you can visit while staying in San Diego • San Diego Convention Center, which you can visit while staying in San Diego • La Jolla Cove, which you can visit while staying in San Diego

Hotels in Otay Mesa, San Diego

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Travel insights for hotels in Otay Mesa

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What is the cheapest month to book a hotel in Otay Mesa?

The cheapest month to book a hotel in Otay Mesa is March ($110). Conversely, the most expensive month to stay in Otay Mesa is April ($182).

What is the cheapest day to stay in a hotel in Otay Mesa?

The cheapest day to stay in Otay Mesa is Monday ($116). On the other hand, travelers can expect to pay the most on Saturday, when the average nightly price is $169.

Cheapest hotels in Otay Mesa, San Diego

These are the lowest prices we've found on hotels in Otay Mesa at the moment. If you have the flexibility, change the dates selected to compare prices.

Hotel prices in Otay Mesa, San Diego

Hotels located in the Otay Mesa area sorted by price and hotel class. As an added layer, we've also marked the most popular and best value properties in each hotel class.

3 stars

2 stars and under

Where to stay in Otay Mesa, San Diego

Explore different neighborhoods and areas within Otay Mesa to find the perfect location for your stay. Map data was last updated on November 10, 2025.

Navigate to the areas in Otay Mesa you plan to visit to find hotels that are close by. Clicking on a hotel name will take you to a page with pricing, reviews, and more useful information.

Facts about staying in Otay Mesa, San Diego

Find useful tips and insights about staying in Otay Mesa to help you make the most of your experience. FAQs were last updated on November 10, 2025.

What are the best hotels in Otay Mesa?

What is a good hotel near Gaslamp Quarter?

What is a good hotel in Otay Mesa near San Diego Convention Center?

Is there a good hotel near La Jolla Cove?

How much is a cheap hotel in Otay Mesa?

What are the most popular landmarks to visit in Otay Mesa?

Find better results for your stay in Otay Mesa

Consider these popular 3-star hotels in Otay Mesa

Stay at one of these Otay Mesa 3-star hotels that users have found on HotelsCombined.