What are the best hotels in Otay Mesa?

Holiday Inn Express & Suites San Diego Otay Mesa By IHG is a very popular hotel in Otay Mesa with a score of 7.4 from 589 reviews.

What is a good hotel near Gaslamp Quarter?

With a rating of 7.8/10 from 4,706 reviews, Wyndham San Diego Bayside is a hotel close to Gaslamp Quarter that is well recommended by HotelsCombined users.

What is a good hotel in Otay Mesa near San Diego Convention Center?

For a good hotel near to San Diego Convention Center, consider Wyndham San Diego Bayside - it is rated 7.8/10 from 4,706 HotelsCombined reviews.

Is there a good hotel near SeaWorld San Diego?

If you’re looking for good hotels near SeaWorld San Diego, consider Paradise Point Resort & Spa (rated 8.0 over 2,082 reviews).

How much is a cheap hotel in Otay Mesa?

HotelsCombined users have found cheap hotels in Otay Mesa starting from $109 per night in the last 3 days.

What are the most popular landmarks to visit in Otay Mesa?

The top three landmarks in Otay Mesa are: • Gaslamp Quarter, which you can visit while staying in San Diego • San Diego Convention Center, which you can visit while staying in San Diego • SeaWorld San Diego, which you can visit while staying in San Diego

Otay Mesa Hotels, in San Diego: Cheap Otay Mesa Hotel Deals

Travel insights for hotels in Otay Mesa

Use our HotelsCombined data-powered tips to help you find your next hotel in Otay Mesa.

What is the cheapest month to book a hotel in Otay Mesa?

The cheapest month to book a hotel in Otay Mesa is January ($110). Conversely, the most expensive month to stay in Otay Mesa is June ($263).

What is the cheapest day to stay in a hotel in Otay Mesa?

The cheapest day to stay in Otay Mesa is Monday ($102). On the other hand, travelers can expect to pay the most on Saturday, when the average nightly price is $232.

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Cheapest hotels in Otay Mesa, San Diego

These are the lowest prices we've found on hotels in Otay Mesa at the moment. If you have the flexibility, change the dates selected to compare prices.

Show all 3 hotels

Quality Suites San Diego Otay Mesa

2351 Otay Center Drive, San Diego, CA, United States

16.6 mi from city centre

Free Wi-Fi

Parking

$119

Avg. per night

View deal

Holiday Inn Express & Suites San Diego Otay Mesa By IHG

2296 Niels Bohr Court, San Diego, CA, United States

16.7 mi from city centre

$134

Avg. per night

View deal

Hotel prices in Otay Mesa, San Diego

Hotels located in the Otay Mesa area sorted by price and hotel class. As an added layer, we've also marked the most popular and best value properties in each hotel class.

3 stars

Quality Suites San Diego Otay Mesa

2351 Otay Center Drive, San Diego, CA, United States

$119

View deal

2 stars and under

Holiday Inn Express & Suites San Diego Otay Mesa By IHG

2296 Niels Bohr Court, San Diego, CA, United States

$134

View deal

Where to stay in Otay Mesa, San Diego

Navigate to the areas in Otay Mesa you plan to visit to find hotels that are close by. Clicking on a hotel name will take you to a page with pricing, reviews, and more useful information.

Facts about staying in Otay Mesa, San Diego

What are the best hotels in Otay Mesa?
Holiday Inn Express & Suites San Diego Otay Mesa By IHG is a very popular hotel in Otay Mesa with a score of 7.4 from 589 reviews.
What is a good hotel near Gaslamp Quarter?
With a rating of 7.8/10 from 4,706 reviews, Wyndham San Diego Bayside is a hotel close to Gaslamp Quarter that is well recommended by HotelsCombined users.
What is a good hotel in Otay Mesa near San Diego Convention Center?
For a good hotel near to San Diego Convention Center, consider Wyndham San Diego Bayside - it is rated 7.8/10 from 4,706 HotelsCombined reviews.
Is there a good hotel near SeaWorld San Diego?
If you’re looking for good hotels near SeaWorld San Diego, consider Paradise Point Resort & Spa (rated 8.0 over 2,082 reviews).
How much is a cheap hotel in Otay Mesa?
HotelsCombined users have found cheap hotels in Otay Mesa starting from $109 per night in the last 3 days.
What are the most popular landmarks to visit in Otay Mesa?
The top three landmarks in Otay Mesa are:
• Gaslamp Quarter, which you can visit while staying in San Diego
• San Diego Convention Center, which you can visit while staying in San Diego
• SeaWorld San Diego, which you can visit while staying in San Diego

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3-Star Hotels

Alternative Stays

Hotels in California

Landmarks

Consider these popular 3-star hotels in Otay Mesa

Quality Suites San Diego Otay Mesa

Travel insights for hotels in Otay Mesa

What is the cheapest month to book a hotel in Otay Mesa?

The cheapest month to book a hotel in Otay Mesa is January ($110). Conversely, the most expensive month to stay in Otay Mesa is June ($263).

What is the cheapest day to stay in a hotel in Otay Mesa?

The cheapest day to stay in Otay Mesa is Monday ($102). On the other hand, travelers can expect to pay the most on Saturday, when the average nightly price is $232.

Cheapest hotels in Otay Mesa, San Diego

These are the lowest prices we've found on hotels in Otay Mesa at the moment. If you have the flexibility, change the dates selected to compare prices.

Hotel prices in Otay Mesa, San Diego

Hotels located in the Otay Mesa area sorted by price and hotel class. As an added layer, we've also marked the most popular and best value properties in each hotel class.

3 stars

2 stars and under

Where to stay in Otay Mesa, San Diego

Explore different neighborhoods and areas within Otay Mesa to find the perfect location for your stay. Map data was last updated on September 23, 2026.

Navigate to the areas in Otay Mesa you plan to visit to find hotels that are close by. Clicking on a hotel name will take you to a page with pricing, reviews, and more useful information.

Facts about staying in Otay Mesa, San Diego

What are the best hotels in Otay Mesa?

What is a good hotel near Gaslamp Quarter?

What is a good hotel in Otay Mesa near San Diego Convention Center?

Is there a good hotel near SeaWorld San Diego?

How much is a cheap hotel in Otay Mesa?

What are the most popular landmarks to visit in Otay Mesa?

Find better results for your stay in Otay Mesa

Consider these popular 3-star hotels in Otay Mesa

Stay at one of these Otay Mesa 3-star hotels that users have found on HotelsCombined.

Consider alternative stays in San Diego

If you are looking for a specific type of hotel, consider these options for trips to San Diego

Explore these cities in California

Looking to explore California during your trip? These are other popular cities nearby that HotelsCombined users visit

Landmarks worth traveling to

Consider seeing these landmarks and special sights

Visit Top Destinations

These destinations around the world are some of the most sought after locations from our users

Popular neighborhoods in San Diego

HotelsCombined users search for hotels in these popular San Diego neighborhoods

Consider these popular San Diego hotel chains

HotelsCombined users tend to book rooms in San Diego at these popular hotel chains

Cities our users search for

Based on the last 12 months of user searches on HotelsCombined

Consider other places to stay in San Diego

Stay at one of these places that users have found on HotelsCombined.

Hotels in Otay Mesa, San Diego

Search and compare Otay Mesa, San Diego hotels from hundreds of travel sites on HotelsCombined and save.

Travel insights for hotels in Otay Mesa

What is the cheapest month to book a hotel in Otay Mesa?

The cheapest month to book a hotel in Otay Mesa is January ($110). Conversely, the most expensive month to stay in Otay Mesa is June ($263).

What is the cheapest day to stay in a hotel in Otay Mesa?

The cheapest day to stay in Otay Mesa is Monday ($102). On the other hand, travelers can expect to pay the most on Saturday, when the average nightly price is $232.

Cheapest hotels in Otay Mesa, San Diego

These are the lowest prices we've found on hotels in Otay Mesa at the moment. If you have the flexibility, change the dates selected to compare prices.

Hotel prices in Otay Mesa, San Diego

Hotels located in the Otay Mesa area sorted by price and hotel class. As an added layer, we've also marked the most popular and best value properties in each hotel class.

3 stars

2 stars and under

Where to stay in Otay Mesa, San Diego

Explore different neighborhoods and areas within Otay Mesa to find the perfect location for your stay. Map data was last updated on September 23, 2026.

Navigate to the areas in Otay Mesa you plan to visit to find hotels that are close by. Clicking on a hotel name will take you to a page with pricing, reviews, and more useful information.

Facts about staying in Otay Mesa, San Diego

What are the best hotels in Otay Mesa?

What is a good hotel near Gaslamp Quarter?

What is a good hotel in Otay Mesa near San Diego Convention Center?

Is there a good hotel near SeaWorld San Diego?

How much is a cheap hotel in Otay Mesa?

What are the most popular landmarks to visit in Otay Mesa?

Find better results for your stay in Otay Mesa

Consider these popular 3-star hotels in Otay Mesa

Stay at one of these Otay Mesa 3-star hotels that users have found on HotelsCombined.

Consider alternative stays in San Diego

If you are looking for a specific type of hotel, consider these options for trips to San Diego

Explore these cities in California

Looking to explore California during your trip? These are other popular cities nearby that HotelsCombined users visit

Landmarks worth traveling to

Consider seeing these landmarks and special sights

Visit Top Destinations

These destinations around the world are some of the most sought after locations from our users

Popular neighborhoods in San Diego

HotelsCombined users search for hotels in these popular San Diego neighborhoods

Consider these popular San Diego hotel chains

HotelsCombined users tend to book rooms in San Diego at these popular hotel chains

Cities our users search for

Based on the last 12 months of user searches on HotelsCombined

Consider other places to stay in San Diego

Stay at one of these places that users have found on HotelsCombined.