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Hotels in Otay Mesa, San Diego

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Travel insights for hotels in Otay Mesa

Use our HotelsCombined data-powered tips to help you find your next hotel in Otay Mesa.

What is the cheapest month to book a hotel in Otay Mesa?

The cheapest month to book a hotel in Otay Mesa is December ($98). Conversely, the most expensive month to stay in Otay Mesa is April ($182).

What is the cheapest day to stay in a hotel in Otay Mesa?

The cheapest day to stay in Otay Mesa is Thursday ($152). On the other hand, travelers can expect to pay the most on Friday, when the average nightly price is $215.
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Cheapest hotels in Otay Mesa, San Diego

Discover affordable stays in Otay Mesa that provide a quality experience without breaking the bank. Hotels in Otay Mesa can be found for as low as $120 per night. There is currently one property in Otay Mesa that can be booked for this price. Quality Suites San Diego Otay Mesa is one of the hotels that can be booked for the lowest price in Otay Mesa. Price data was last updated on August 7, 2025
These are the lowest prices we've found on hotels in Otay Mesa at the moment. If you have the flexibility, change the dates selected to compare prices.
Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa

2351 Otay Center Drive, San Diego, CA, United States
16.6 mi from city centre
Free Wi-Fi
Parking
$120
Avg. per night
View Deal
Holiday Inn Express & Suites San Diego Otay Mesa By IHG
Holiday Inn Express & Suites San Diego Otay Mesa By IHG

Holiday Inn Express & Suites San Diego Otay Mesa By IHG

2296 Niels Bohr Ct, San Diego, CA, United States
16.7 mi from city centre
Free Wi-Fi
$141
Avg. per night
View Deal

Hotel prices in Otay Mesa, San Diego

Get a sense of the average price and most popular properties to stay in Otay Mesa to help you budget for your trip accordingly. Hotels that are booked the most in each class receive the “Most popular” badge. Hotels with the “Best value” badge are the most popular hotels in Otay Mesa at attractive prices. Price data was last updated on August 7, 2025.
Hotels located in the Otay Mesa area sorted by price and hotel class. As an added layer, we've also marked the most popular and best value properties in each hotel class.
3 stars
Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa

2351 Otay Center Drive, San Diego, CA, United States
$120
View Deal
2 stars and under
Holiday Inn Express & Suites San Diego Otay Mesa By IHG
Holiday Inn Express & Suites San Diego Otay Mesa By IHG

Holiday Inn Express & Suites San Diego Otay Mesa By IHG

2296 Niels Bohr Ct, San Diego, CA, United States
$141
View Deal

Where to stay in Otay Mesa, San Diego

Explore different neighborhoods and areas within Otay Mesa to find the perfect location for your stay. Map data was last updated on August 7, 2025.
Navigate to the areas in Otay Mesa you plan to visit to find hotels that are close by. Clicking on a hotel name will take you to a page with pricing, reviews, and more useful information.

Facts about staying in Otay Mesa, San Diego

Find useful tips and insights about staying in Otay Mesa to help you make the most of your experience. FAQs were last updated on August 7, 2025.

  • What are the best hotels in Otay Mesa?

    Holiday Inn Express & Suites San Diego Otay Mesa By IHG is a very popular hotel in Otay Mesa with a score of 7.5 from 596 reviews.

  • What is a good hotel near La Jolla Cove?

    With a rating of 7.8/10 from 16 reviews, La Jolla Shores Hotel is a hotel close to La Jolla Cove that is well recommended by HotelsCombined users.

  • What is a good hotel in Otay Mesa near San Diego Convention Center?

    For a good hotel near to San Diego Convention Center, consider Hilton San Diego Bayfront - it is rated 7.7/10 from 2,970 HotelsCombined reviews.

  • Is there a good hotel near Gaslamp Quarter?

    If you’re looking for good hotels near Gaslamp Quarter, consider Hilton San Diego Bayfront (rated 7.7 over 2,970 reviews).

  • How much is a cheap hotel in Otay Mesa?

    HotelsCombined users have found cheap hotels in Otay Mesa starting from $113 per night in the last 3 days.

  • What are the most popular landmarks to visit in Otay Mesa?

    The top three landmarks in Otay Mesa are:
    • La Jolla Cove, which you can visit while staying in San Diego
    • San Diego Convention Center, which you can visit while staying in San Diego
    • Gaslamp Quarter, which you can visit while staying in San Diego

See more FAQs

Find better results for your stay in Otay Mesa

Consider these popular 3-star hotels in Otay Mesa

Stay at one of these Otay Mesa 3-star hotels that users have found on HotelsCombined.
Quality Suites San Diego Otay Mesa

Search cheap hotels with HotelsCombined. Use the hotel finder to search for the cheapest hotel deal for all major destinations around the world. HotelsCombined searches hundreds of hotel booking sites to help you find hotels and book hotels that suit you best. Since HotelsCombined searches many hotel sites at once, you can find discount hotels quickly, including Hotels Under $50 and Hotels Under $100. Discover hotel discounts now and make your hotel reservation today.