Insights
Cheapest hotels
Where to stay

Hotels in Otay Mesa, San Diego

Search and compare Otay Mesa, San Diego hotels from hundreds of travel sites on HotelsCombined and save.

...and more

Learn why travelers love HotelsCombined

Compare hotel ratings collected from thousands of user reviews.

One search gives you accurate pricing on affordable hotels.

Customize your results by hotel chain, amenities, price and more.

Search for hotels as many times as you want – for free.

Travel insights for hotels in Otay Mesa

Use our HotelsCombined data-powered tips to help you find your next hotel in Otay Mesa.

What is the cheapest month to book a hotel in Otay Mesa?

The cheapest month to book a hotel in Otay Mesa is January ($110). Conversely, the most expensive month to stay in Otay Mesa is June ($232).

What is the cheapest day to stay in a hotel in Otay Mesa?

The cheapest day to stay in Otay Mesa is Wednesday ($103). On the other hand, travelers can expect to pay the most on Monday, when the average nightly price is $158.

Find deals

Cheapest hotels in Otay Mesa, San Diego

Discover affordable stays in Otay Mesa that provide a quality experience without breaking the bank. Hotels in Otay Mesa can be found for as low as $114 per night. There is currently one property in Otay Mesa that can be booked for this price. Quality Suites San Diego Otay Mesa is one of the hotels that can be booked for the lowest price in Otay Mesa. Price data was last updated on March 26, 2026
These are the lowest prices we've found on hotels in Otay Mesa at the moment. If you have the flexibility, change the dates selected to compare prices.
Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa

2351 Otay Center Drive, San Diego, CA, United States
16.6 mi from city centre
Free Wi-Fi
Parking
$114
Avg. per night
View Deal
Holiday Inn Express & Suites San Diego Otay Mesa By IHG
Holiday Inn Express & Suites San Diego Otay Mesa By IHG

Holiday Inn Express & Suites San Diego Otay Mesa By IHG

2296 Niels Bohr Court, San Diego, CA, United States
16.7 mi from city centre
$136
Avg. per night
View Deal

Hotel prices in Otay Mesa, San Diego

Get a sense of the average price and most popular properties to stay in Otay Mesa to help you budget for your trip accordingly. Hotels that are booked the most in each class receive the “Most popular” badge. Hotels with the “Best value” badge are the most popular hotels in Otay Mesa at attractive prices. Price data was last updated on March 26, 2026.
Hotels located in the Otay Mesa area sorted by price and hotel class. As an added layer, we've also marked the most popular and best value properties in each hotel class.
3 stars
Quality Suites San Diego Otay Mesa
Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa

2351 Otay Center Drive, San Diego, CA, United States
$114
View Deal
2 stars and under
Holiday Inn Express & Suites San Diego Otay Mesa By IHG
Holiday Inn Express & Suites San Diego Otay Mesa By IHG

Holiday Inn Express & Suites San Diego Otay Mesa By IHG

2296 Niels Bohr Court, San Diego, CA, United States
$136
View Deal

Where to stay in Otay Mesa, San Diego

Explore different neighborhoods and areas within Otay Mesa to find the perfect location for your stay. Map data was last updated on March 26, 2026.
Navigate to the areas in Otay Mesa you plan to visit to find hotels that are close by. Clicking on a hotel name will take you to a page with pricing, reviews, and more useful information.

Facts about staying in Otay Mesa, San Diego

Find useful tips and insights about staying in Otay Mesa to help you make the most of your experience. FAQs were last updated on March 26, 2026.

  • What are the best hotels in Otay Mesa?

    Holiday Inn Express & Suites San Diego Otay Mesa By IHG is a very popular hotel in Otay Mesa with a score of 7.5 from 599 reviews.

  • What is a good hotel near Gaslamp Quarter?

    With a rating of 7.8/10 from 3,968 reviews, Wyndham San Diego Bayside is a hotel close to Gaslamp Quarter that is well recommended by HotelsCombined users.

  • What is a good hotel in Otay Mesa near San Diego Convention Center?

    For a good hotel near to San Diego Convention Center, consider Wyndham San Diego Bayside - it is rated 7.8/10 from 3,968 HotelsCombined reviews.

  • Is there a good hotel near Mission Beach?

    If you’re looking for good hotels near Mission Beach, consider Paradise Point Resort & Spa (rated 8.1 over 1,953 reviews).

  • How much is a cheap hotel in Otay Mesa?

    HotelsCombined users have found cheap hotels in Otay Mesa starting from $113 per night in the last 3 days.

  • What are the most popular landmarks to visit in Otay Mesa?

    The top three landmarks in Otay Mesa are:
    • Gaslamp Quarter, which you can visit while staying in San Diego
    • San Diego Convention Center, which you can visit while staying in San Diego
    • Mission Beach, which you can visit while staying in San Diego

See more FAQs

Find better results for your stay in Otay Mesa

Consider these popular 3-star hotels in Otay Mesa

Stay at one of these Otay Mesa 3-star hotels that users have found on HotelsCombined.
Quality Suites San Diego Otay Mesa