Florence City Centre is the downtown heart of the capital city of Florence located near the centre of Tuscany, Italy. The area is listed geographically within Quartiere 1 and known as a prominent UNESCO World Heritage Site. The City Centre is a collection of historical and cultural monuments, museums, and cathedrals reflecting classic Renaissance style.

Cultural icons within the Florence City Centre include the Piazza del Duomo known as one of the most visited tourist attractions, the Cathedral of Santa Maria del Fiore being the most popular cathedral, and the Basilica of Saint Lawrence. Other interests consist of the Palazzo Pitti containing the largest concentration of museums in Italy and the Palazzo Strozzi with its variety of exhibitions. Additionally, the Florence City Centre is a shopping and entertainment hotspot.

The Florence Airport is located 15 minutes from the Florence City Centre. The Firenze Santa Maria Novella railway station is the primary Florence tramway station connected to the limited high-speed railways that access the city centre. The historic area itself is restricted from through traffic, and only permitted buses and taxis are allowed in effect to decrease pollution.

The City Centre of Florence is a living portfolio of the most masterful artists of the Renaissance period, most notably Giotto, Brunelleschi, Botticelli and Michelangelo. The architectural style capitalised by the city centre transformed the construction of subsequent European meccas across the continent.